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p155
APOE (apolipoprotein E) that is involved in cholesterol transport and processing, and it has three variants: e2, e3, and e4. Of these, e3 is the most common by far, but having one or two copies of the e4 variant seems to multiply one’s risk of developing Alzheimer’s disease by a factor of between two and twelve
The e2 variant of APOE, on the other hand, seems to protect its carriers against dementia
people who carried at least one copy of APOE e2 (and no e4) were about 30 percent more likely to reach extreme old age (defined as ninety-seven for men, one hundred for women) than people with the standard e3/e3 combination.
SNPs (or variants) in FOXO3 that were strongly associated with healthy aging and longevity.
Rising levels of ALT are often the first clue that something is wrong with the liver, although they could also be a symptom of something else, such as a recent viral infection or a reaction to a medication.
acceptable range for ALT is below 33 IU/L for women and below 45 IU/L for men
obese (defined as having a BMI[*2] greater than 30), while roughly another third is overweight (BMI of 25 to 30)
Metabolic Syndrome
high blood pressure (>130/85)
high triglycerides (>150 mg/dL)
low HDL cholesterol (<40 mg/dL in men or <50 mg/dL in women)
central adiposity (waist circumference >40 inches in men or >35 in women)
elevated fasting glucose (>110 mg/dL)
This is why I insist my patients undergo a DEXA scan annually—and I am far more interested in their visceral fat than their total body fat.